In macOS 10.13 or above, drivers were installed but the device does not appear to OS. Lynx Mixer will not launch.

Starting with macOS 10.13 (High Sierra), Apple has added a new security feature that prevents third-party kernel extensions from loading without specific user authorization.  For more information about this from Apple, please see TN2459.  

Specifically, when the Hilo-Thunderbolt is first plugged in, you should see two entries in the System Information panel.  The first under Thunderbolt, LT-TB should appear:

The second under PCI, pci1621,14 "Audio" should appear:  

This is the LT-TB installed in the Hilo.  Since no driver is loaded yet, the driver hasn't had a chance to rename the PCI device to Hilo.

After the driver has been installed successfully, the pci1621,14 should change to Hilo.

To install the driver completely, first open the Lynx_OSX.pkg that was downloaded from the www.lynxstudio.com web site.  After the driver installs, you should receive a message that a Kernel Extension has been blocked.  Go into the Security & Privacy of the Systems Preferences pane, and click "Allow" for the Lynx Studio Technology extension.  Once you restart your system the driver should load properly.