The Hilo-USB is currently supported on Big Sur with both the Intel and Apple Silicon M1 chip.
The Hilo-TB3 and Hilo-TB are currently supported on Big Sur for Macintosh with the Intel and Apple Silicon M1 chip.
Dante support is provided by Audinate. Audinate current supports Big Sur on the Intel platform. Please see the Audinate web page for complete information on Dante Big Sur support.